A quick way to automate making multiple maps covering a large area is through Data Driven Pages. Whether you are trying to follow a road, or if you want to grid an area and show sections on individual maps, there are ways to automate this in ArcGIS so that you have a consistent maps.
There are multiple ways to use Data Driven pages for automated map production.
I have outlined 3 different scenarios where you may find it easier to create maps using data driven pages than individually
Following a Line Feature
1. Search for the ‘Strip Map Index Feature’ Tool in the Search Window
2. Set tool parameters
Layer = Line you would like to follow
Length = the page dimensions you would like to be displayed